Construct a 5- to 6-page paper discussing each of the four traditional mood stabilizer medications: carbamazepine, lamotrigine, lithium, and valproate products. Support your answers with five (5) evidence-based, peer-reviewed scholarly literature.

  

 

Note: APA style format will apply.

 

Your paper should include the following for each:

 

Proposed mechanism of action

Baseline assessment, laboratory considerations, and frequency of ongoing labs and assessments

Note: Discuss the importance of assessment and labs.

Special population considerations (birth assigned gender, age, other medical comorbidity considerations)

FDA approval indications

Typical dosing with discussion on therapeutic endpoints for psychiatric use

Major drug–drug interaction considerations

For each of these medications, please review potential drug–drug interactions listed below. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professions (such as, primary care providers)

Lamotrigine + Valproate

Lamotrigine + Rifampin

Valproate + Estrogen containing birth control.

Valproate + Amitriptyline

Lithium + Furosemide

Lithium + Lisinopril

Carbamazepine + Lurasidone

Carbamazepine + Grapefruit juice

Discuss the ethical, legal, and social implications related to prescribing bipolar and other related mood-disorder diagnoses therapy for patients.

Reminder: The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. For this Assignment, you are only required to include a title page. The Walden Writing Center Sample PaperLinks to an external site. provides an example of those required elements.

 

Reading Resources:

 

Goldin, D. S. (2023). Fast facts for psychopharmacology for nurse practitioners. Springer Publishing.

Chapter 8, “Mood Stabilizers“ (pp. 150—178)

Stahl, S. M. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (5th ed.). Cambridge University Press. 

Chapter 6, "Mood Disorders and the Neurotransmitter Networks Norepinephrine and y-Aminobutyric Acid (GABA)" (pp. pp. 244—282) 

American Psychiatric Association. (2010). Practice guideline for the treatment of patients with bipolar disorderLinks to an external site. (2nd ed.). APA. https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/bipolar.pdf

Drugs.comLinks to an external site.. (2023). https://www.drugs.com/

Note: Please use the following resource to check the most up-to-date box warnings, FDA approvals and indications, recommendations for follow-up evaluations, changes, etc.

Approved Medications for Bipolar and Related Mood Disorders

Note: Utilize the following medication table to familiarize yourself with the medications aligned with the topics presented this week.