Developing a Searchable PICO(T) Question for Clinical Inquiry Responding to Kimberly
Hi Kimberly,
This is a very insightful post! Your comprehensive exploration of the clinical issue surrounding treatment-resistant major depressive disorder (TRMDD) and suicidal ideation (SI) demonstrates a commendable commitment to understanding the gravity of the situation. The statistics from the CDC emphasize the urgent need for effective interventions, and your strategic approach to article search is meticulous.
I concur with your emphasis on the ethical dimension of addressing TRMDD and SI as a mass concern for medical management. However, while ketamine has shown promise in some studies, it’s crucial to consider the broader context and potential ethical implications of its use (Lapidos et al., 2023). Additionally, your proposed future strategies for database searches are apt, but ensuring a nuanced evaluation of outcomes, risks, and patient profiles should remain a priority. Overall, your diligence in research and ethical considerations is evident, and I appreciate your dedication to finding viable solutions for such a pressing public health issue.
References
Lapidos, A., Lopez-Vives, D., Sera, C. E., Ahearn, E., Vest, E., Senic, I., Vande Voort, J. L., Frye, M., Goes, F. S., Achtyes, E., Greden, J., & Parikh, S. V. (2023). Patients’ recovery and non-recovery narratives after intravenous ketamine for treatment-resistant depression. Journal of Affective Disorders, 323, 534–539. https://doi.org/10.1016/j.jad.2022.11.090
Responding to Anna Cooper
Hi Anna,
This is a great post! Your detailed exploration of the insulin cost issue is commendable. The statistics you provided effectively highlight the magnitude of the problem, emphasizing the urgency of finding solutions. Your approach to filtering search results for scholarly and recent publications demonstrates a commitment to academic rigor.
I agree with your consideration of pharmacy benefit managers as potential culprits in insulin price manipulation (Knox, 2020). This aligns with existing literature pointing to their role in exacerbating the issue. To enhance your analysis, consider delving deeper into specific case studies or policy implications that address the actions of pharmacy benefit managers. Additionally, incorporating patient perspectives and the impact on healthcare disparities could provide a more comprehensive understanding of the issue.
Furthermore, expanding your search to international perspectives may offer insights into successful strategies employed in other countries to control insulin costs. Collaborating with healthcare economists or policy experts could also enrich your discussion. Overall, your groundwork is solid, and further exploration along these lines could strengthen the depth and breadth of your research.
References
Knox, R. (2020). Insulin insulated: barriers to competition and affordability in the United States insulin market. Journal of Law and the Biosciences, 7(1). https://doi.org/10.1093/jlb/