DIABETES AND DRUG TREATMENTS

Hello Karla,

Your discussion is very informative. It presents information that helps people understand the various types of diabetes and associated complications. Your focus on Type 1 diabetes is a good choice. The prevalence rate of Type 1 diabetes is fast rising. Recent data compiled for the past 3 decades show a 3 to 4 percent increase in type 1 diabetes incidence rates (Norris et al., 2020). There are multiple factors contributing to these changes in the epidemiology. As you have noted, Type 1 diabetes is a result of reduced B-cell function due to the complex interaction between the pancreatic B-cell and adaptive immune systems. current evidence is moving from blaming immunity alone to indicating that environmental factors are contributing to the disease of the B-cells, leading to impaired functionality (Roep et al., 2020). Such new evidence can help inform new targeted interventions for managing and treating Type 1 diabetes and overcoming related complications.

References

Norris, J. M., Johnson, R. K., & Stene, L. C. (2020). Type 1 diabetes—early life origins and changing epidemiology. The Lancet Diabetes & Endocrinology, 8(3), 226–238. https://doi.org/10.1016/S2213-8587(19)30412-7

Roep, B. O., Thomaidou, S., van Tienhoven, R., & Zaldumbide, A. (2020). Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?). Nature Reviews Endocrinology 2020 17:3, 17(3), 150–161. https://doi.org/10.1038/s41574-020-00443-4