Discuss the role inflammatory cytokines play in the development and exacerbation of bipolar type 2 symptoms

Inflammatory cytokines play some role in the development and exacerbation of bipolar type 2 symptoms. Cytokines are proteins involved in the regulation and orchestration of the immune response. Cytokines can directly affect neuronal activity, thus inducing neuronal excitability and plastic changes in the mood regulating areas of the brain and neuroprogression of the bipolar diathesis. Besides, inflammatory cytokines influence the symptoms and exacerbation of type 2 bipolar by influencing the HPA through effects on HPA axis as it increases the levels of cortisol hormone