Exploring the Effects of Fluid Imbalances, Anemia Types, Insulin-Potassium Relationships, and Autoimmune Disorders Hello Dr. Garrett

To answer the first question on the impact on cells with hypo/hypertonic fluids, hypertonic fluids are those that have a greater concentration of solitudes than the inside of blood cells and, therefore, cause them to shrivel. The phenomena, explained in simpler terms, means that water from inside the cells gets lost at a higher rate than when the cells absorb water.

To answer the second question, the symptoms presented by the patient show a deficiency of Hct and high levels of MCV. The patient is an adult male and should have an average Hct level ranging between 40 to 50 and an average MCV level between 80 to 100l (Ademoğlu et al. 2020). The possible prognosis, in this case, is severe anemia or macrocytic anemia. The patient should undergo a CBC test and if the tests prove to be positive, proceed with a peripheral blood smear test for macrocytic anemia. Recommend the patient for IV injection, pain relievers, and oral and intravenous fluids for relieving pain. Folic acid supplements, blood transfusions, and antibiotics can also be an alternative. To manage macrocytic anemia, folate and vitamin B supplements should be recommended, and if the problem persists, vitamin B-12 injections should be ordered.

For the third question on the type of anemia seen with sickle cell disease, the genetic condition that affects red blood cells is characterized by two types of cell genes that can be inherited. The patient shows symptoms at the early stages of life, normally at five months, indicating very low levels of red blood cells.

The fourth question asked about the relationship between insulin and potassium. Insulin and potassium in the bodywork interchangeably to benefit each other’s concentration and levels in the body to prevent Hypokalemia and high blood sugar levels. Insulin helps increase potassium levels whenever they exceed the minimum through increasing cell permeability to potassium and, therefore, can be induced in the prevention of Hypokalemia. Potassium is responsible for the release of insulin in the body, and consequently, moderate levels of potassium help maintain normal blood sugar levels. Since low levels of insulin cause high blood sugar levels, potassium helps control insulin in the body, thus influencing sugar levels.

The last question asked to list an autoimmune disease I have learned, its risk factors, and the presenting signs and symptoms. Rheumatoid arthritis is caused by the immune system’s mistaken attack of healthy body cells in an assumed reaction to infection. The known risk factors for this condition include genetic inheritance, obesity, and smoking. Old age and early exposure to smoking can also cause the disease; research further shows that women have a higher prevalence of this condition than men. The symptoms include pain in the joints, fever, fatigue, and loss of appetite; the joints may be stiff and appear swollen or tender.

References

Ademoğlu, E., Canbulat, E. C., Falay, M., Fırtına, S., Genç, S., Karakükçü, Ç., … & Güner, İ.  (2020). Association of Clinical Biochemistry Specialists Preanalytic Phase Symposium on Hematology Tests.

Hello Parminder

Great response!! I agree with your pathophysiology of wound healing as a reaction to an injury involving cellular actors and structures systematically structured and executed in the process. The first phase of wound healing is homeostasis or coagulation, characterized by the initiation of cascade and fibrin strands forming clots on the affected region (Kaplani et al., 2018). The second phase is inflammatory cell recruitment to kill infections and remove damaged cells. The third phase is proliferation, which covers and fills the wound by utilizing stimulated and differentiated fibroblasts to create wound boundaries. The maturation phase is final and involves tissue remodeling and an increase in flexibility and strength by epithelialization.

Granuloma and its significance

When it comes to granuloma and its importance, I think your description is insightful. However, I can explain it in simple terms as the defensive mechanism that signals the body to develop an intracellular defense for infection-causing pathogens.

Regarding your post about graft versus host disease, I agree that there is no concern for Graft-versus-host disease at this stage since the patient’s wound has already been covered with Sutures. It can only become a concern if the wound opens up and the healing process is delayed. Since laceration is a common condition and most often heals by itself when managed and treated early, it is recommended to wait for healing and only raise the alarm if the healing prolongs.

References

Kaplani, K., Koutsi, S., Armenis, V., Skondra, F. G., Karantzelis, N., Tsaniras, S.