One of Ella’s children brought her a new pair of slippers to wear in the nursing home. A minute after she received them, Ella could not remember the exchange and asked what they were doing on her bed. What part of the brain has largely been affected to produce this behavior, and what is the pathophysiology involved?

As mentioned there are structural changes in the brain associated with AD, such as the abnormalities in the neurotransmitters, such as ACh, dopamine, norepinephrine, and serotonin[Ign17]. High levels of the beta amyloid proteins are associated with the reduced ACh, which leads to decrease in acetyltransferase interferes with cholinergic innervation to the cerebral cortex [Ign17]. This results in impaired cognition, recent memory loss, and the inability to acquire new memory