Q5. Are there any interactions between any of the medications you prescribed?

 

There have been reports on the pharmacological interaction between thiazide

diuretics and various drugs, including lithium, angiotensin-converting enzyme

inhibitors, non-steroidal anti-inflammatory drugs, antidiabetic medications, and

Vitamin D (Maideen, 2020). The potential interactions between thiazides and herbs

such as licorice and ginkgo have also been investigated.

Calcium channel blockers (CCBs) exhibit a multitude of significant drug

interactions (McKeever & Hamilton, 2022). The administration of verapamil and

diltiazem has been observed to result in an elevation of digoxin levels. The

administration of verapamil, diltiazem, and nicardipine has been observed to

elevate plasma concentrations of cyclosporine while concurrently reducing the

necessary dosage of the latter. The metabolism of Verapamil and diltiazem is

mediated by the enzyme CYP3A4. Consequently, substances that induce the

activity of this enzyme, such as rifampin, are expected to lead to reduced plasma

concentrations of these two calcium channel blockers (CCBs). Conversely,

substances that inhibit the activity of CYP3A4, such as erythromycin and

cimetidine, are likely to result in increased plasma levels of Verapamil and